Metronidazole is an antibiotic used to fight bacteria in your body. Learn about side effects, interactions and indications. Metronidazole is a nitroimidazole with antiprotozoal, antibacterial, and anti-inflammatory properties and is available in oral and topical formulations. The diverse mechanisms of action of metronidazole have expanded its utility across various dermatologic conditions. What is metronidazole topical? Metronidazole topical (for the skin) is used to treat skin lesions caused by rosacea. Metronidazole topical may also be used for purposes not listed in this medication guide. Description Metronidazole topical gel is used to treat inflammatory lesions (pimples and red bumps) caused by rosacea. Rosacea is a skin disease that causes redness and pimples on your nose, cheeks, chin, and forehead. This medicine is available only with your doctor's prescription. Find patient medical information for Metronidazole topical on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Metronidazole gel and cream are antimicrobial skin preparations. They are used to treat rosacea or to reduce unpleasant smells from infected wounds. For rosacea, apply a thin layer twice daily, usually for weeks or months. For wounds, it is usually applied once or twice daily after cleaning. Metronidazole cream, gel, and lotion are for topical use only and patients should apply a thin layer to the afected areas once-twice daily. Studies have demonstrated that for both the 0.75% and 1% formulations, once daily application of topical metronidazole is as efective as twice daily application. Metronidazole is a topical cream used for treating acne rosacea by reducing swelling and redness. Side effects of metronidazole include irritation, skin dryness, scaling, and itching at the site of application. Consult your doctor if pregnant or breastfeeding. About this medication METRONIDAZOLE (me troe NI da zole) treats rosacea. It works by decreasing inflammation and killing or preventing the growth of bacteria on your skin. Metronidazole cream is a medication that treats rosacea by decreasing inflammation and destroying bacteria growth on your skin. Rosacea causes redness and inflammation on your face.